Chapter: Attrition in Drug Discovery and Development

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Home > Attrition in the Pharmaceutical Industry: Reasons, Implications, and Pathways Forward > Attrition in Drug Discovery and Development

Attrition in the Pharmaceutical Industry: Reasons, Implications, and Pathways Forward |

Alexander Alex; C. John Harris; Dennis A. Smith

John Wiley & Sons

Attrition in the Pharmaceutical Industry: Reasons, Implications, and Pathways Forward

Attrition in Drug Discovery and Development

Chapter Info

Authors

Scott Boyer; Clive Brealey; Andrew M. Davis

ARI Id

1668173538430_20630978

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Not Available Free

Pages

5-45

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Chapters/Headings	Author(s)	Pages	Info
Front Matter		i-xiv
Introduction	Alexander Alex; John Harris; Dennis A. Smith	1-4
Attrition in Drug Discovery and Development	Scott Boyer; Clive Brealey; Andrew M. Davis	5-45
Compound Attrition at the Preclinical Phase	Cornelis E.C.A. Hop	46-82
Attrition in Phase I	Dennis A. Smith; Thomas A. Baillie	83-105
Compound Attrition in Phase II/III	Alexander Alex; C. John Harris; Wilma W. Keighley; Dennis A. Smith	106-127
Postmarketing Attrition	Dennis A. Smith	128-157
Influence of the Regulatory Environment on Attrition	Robert T. Clay	158-179
Experimental Screening Strategies to Reduce Attrition Risk	Marie-Claire Peakman; Matthew Troutman; Rosalia Gonzales; Anne Schmidt	180-214
Medicinal Chemistry Strategies to Prevent Compound Attrition	J. Richard Morphy	215-228
Influence of Phenotypic and Target-Based Screening Strategies on Compound Attrition and Project Choice	Andrew Bell; Wolfgang Fecke; Christine Williams	229-263
In Silico Approaches to Address Compound Attrition	Peter Gedeck; Christian Kramer; Richard Lewis	264-286
Current and Future Strategies for Improving Drug Discovery Efficiency	Peter Mbugua Njogu; Kelly Chibale	287-328
Impact of Investment Strategies, Organizational Structure and Corporate Environment on Attrition, and Future Investment Strategies to Reduce Attrition	Geoff Lawton	329-352
Index		353-356
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